In vivo activation of the NLRP3 inflammasome in neutrophils required both host-derived and bacterial-derived signals. Using a model of invasive pneumococcal disease, we highlighted an unexpected key role for neutrophils as accessory cells in innate interleukin (IL)-17A production by lung resident Vg6Vd1+ Tcells via nucleotide-binding oligomerization domain receptor, pyrin-containing 3 (NLRP3) inflammasome-dependent IL-1b secretion. Organizations may consider developing criteria for alerts that focus on real chances of patient harm while preventing alert fatigue, minimizing the need for or use of overrides.Traditionally regarded as simple foot soldiers of the innate immune response limited to the eradication of pathogens, neutrophils recently emerged as more complex cells endowed with a set of immunoregulatory functions. Of the 583 event reports related to the use of overrides, the most commonly mentioned technology was automated dispensing cabinets (77.0%, n = 449), followed by computerized prescriber order entry (8.2%, n = 48) and bar-code medication administration devices (7.5%, n = 44).The most common classes of medications cited were antibiotics (12.0%, n = 70), opioids, (12.0%, n = 70), and anticoagulants (7.4%, n = 43) and 26.4% (n = 154) of the reports involved at least one high-alert medication. Analysts reviewed medication error event reports that indicated the use of overrides submitted from January 2013 through December 2014 to the Pennsylvania Patient Safety Reporting System. Users can bypass many of the safety features incorporated in medication-use technologies that provide warnings about possible unsafe conditions or errors.
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